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Case Report
 
Bilateral chest wall sarcomas associated with silicone implant capsules in a patient with Li-Fraumeni syndrome
Meenakshi Bansal1, Stephenn Vega2, Gabrielle A. Yeaney3, Xi Wang4
1MD, Resident, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642.
2MD, Assistant Professor, Department of Plastic Surgery, University of Rochester Medical Center, Rochester, NY 14642.
3MD, Assistant professor, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642.
4MD, Associate professor, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642.

Article ID: 100006Z11MB2016
doi:10.5348/Z11-2016-6-CR-2

Address correspondence to:
Xi Wang
Department of Pathology
601 Elmwood Ave
Rochester, NY
U.S.A 14642

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How to cite this article:
Bansal M, Vega S, Yeaney GA, Wang Xi. Bilateral chest wall sarcomas associated with silicone implant capsules in a patient with Li-Fraumeni syndrome. J Case Rep Images Pathol 2016;2:6–9.


Abstract
Introduction: The carcinogenicity of silicone implants has been confirmed in rodents but is not evident in human breast.
Case Report: We report a patient with Li-Fraumeni syndrome who developed bilateral chest wall unclassified sarcomas tightly associated with the capsule of silicone implants placed during treatment for her right breast cancer.
Conclusion: Our case may suggest that genetic instability could increase the probability of carcinogenesis of silicone implants. Caution should be exercised when making management plans for these patients.

Keywords: Breast cancer, Li-Fraumeni syndrome, Sarcoma, Silicone implant


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Author Contributions
Meenakshi Bansal – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Stephenn Vega – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Gabrielle A. Yeaney – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Xi Wang – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 Meenakshi Bansal et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.