Introduction: Neutrophilic eccrine hidradenitis (NEH) is a rare and benign condition, which belongs to the spectrum of neutrophilic dermatoses. In this paper, we present a case of NEH during administration of chemotherapy for the treatment of acute myeloid leukemia along with histological and clinical findings.
Case Report: This paper presents the case of a 69-year-old male with a history of ulcerative colitis, dyslipidemia, and hypertension. He was diagnosed with acute myeloid leukemia. From day-1 of admission until day-7, the patient was administered cytarabine 200 mg/m². In addition, idarubicin (12 mg/m²) was initiated on day-3. On day-21, a morbilliform, diffused, pruritic, infiltrated rash was observed. A fresh cutaneous biopsy revealed that these lesions were of viral origin or reaction, without signs of malignant proliferation. The periodic acid Schiff coloration test was negative for infection. The lesions regressed spontaneously after the introduction of amphotericin B and vancomycin.
Conclusion: We concluded that neutrophilic eccrine hidradenitis is self-limiting and non-life-threatening. However, early diagnosis of the condition is necessary to avoid unwarranted medication and surgery. Neutrophilic eccrine hidradenitis can be successfully managed with the use of topical or systemic corticosteroids. Analgesics may be useful in case of pain. Dose adjustment or changing the chemotherapeutic agent is recommended to avoid possible recurrence.