Case Report


Sarcina ventriculi-associated with chemotherapy-induced ischemic-like gastric injury in a patient with transformed high-grade B-cell lymphoma: A case report

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1 MD, Pathology Department, McLaren Flint, 401 S. Ballenger Hwy, Flint, MI, USA

Address correspondence to:

Baraa Alosh

Pathology Department, McLaren Flint, 401 S. Ballenger Hwy, Flint, MI 48532,

USA

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Article ID: 100036Z11WA2020

doi: 10.5348/100036Z11WA2020CR

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How to cite this article

Alkaram W, Liu W, Alosh B. Sarcina ventricul-iassociated with chemotherapy-induced ischemic-like gastric injury in a patient with transformed high-grade B-cell lymphoma: A case report. J Case Rep Images Pathol 2020;6:100036Z11WA2020.

ABSTRACT


Introduction: Sarcina ventriculi is a Gram-positive coccus bacterium that has a distinctive morphologic appearance resembling the chambers of a heart. It is widely spread in the soil and can contaminate the food. However, it rarely causes a disease in a healthy individual. There has been a recent surging in the reporting of S. ventriculi in the medical literature, particularly in patients with delayed gastric emptying for various reasons. It can be associated with life-threatening conditions, such as emphysematous gastritis and perforation.

Case Report: We report here the first case of S. ventriculi in association with a chemotherapy-treated patient for a lymphoma. An 81-year-old man with a history of high-grade B-cell lymphoma status-post-chemotherapy, presented with abdominal pain, loss of appetite, and weight loss. There was no evidence of relapsed lymphoma by imaging studies. An esophagogastroduodenoscopy showed a gastric mucosa with a large mass effect and erythema. Histologic examination showed ischemic-like gastritis with numerous basophilic microorganisms with morphology consistent with S. ventriculi. The patient was discharged with a course of antibiotics, including metronidazole, ciprofloxacin, and vancomycin.

Conclusion: Recognizing S. ventriculi in gastric biopsies is essential because some cases can be associated with severe morbidity and mortality, particularly in patients with previous morbidities like malignancies.

Keywords: Chemotherapy, Gastritis, Lymphoma, Sarcina ventriculi

SUPPORTING INFORMATION


Author Contributions

Waed Alkaram - Acquisition of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Weimin Liu - Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Baraa Alosh - Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Guarantor of Submission

The corresponding author is the guarantor of submission.

Source of Support

None

Consent Statement

Written informed consent was obtained from the patient for publication of this article.

Data Availability

All relevant data are within the paper and its Supporting Information files.

Conflict of Interest

Authors declare no conflict of interest.

Copyright

© 2020 Waed Alkaram et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.