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Case Report
Multinucleated cell angiohistiocytoma: A case report and literature review
1 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
2 Department of Pathology and Molecular Medicine, St. Joseph’s Hospital, Hamilton, Ontario, Canada
Address correspondence to:
Salem Alowami
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario,
Canada
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Article ID: 100037Z11AS2020
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Shah A, Salama S, Gohla G, Alowami S. Multinucleated cell angiohistiocytoma: A case report and literature review. J Case Rep Images Pathol 2020;6:100037Z11AS2020.ABSTRACT
Introduction: Multinucleate cell angiohistiocytoma (MCAH) is a rare vascular and fibrohistiocytic tumor of the skin with characteristic component of multinucleated giant cells. Herein, we discuss the case with clinicopathologic correlation of MCAH with two rare cutaneous tumors containing multinucleated giant cells: giant cell fibroblastoma (GCF) and dermatofibroma with monster cells (DFMC). Clinical and histopathological characteristics of these three lesions have not been compared before. It is our aim to help highlight the key differences that will help pathologists differentiate between MCAH, DFMC, and GCFB.
Case Report: We report a case of a 68-year-old woman with a skin lesion from her thigh, which was initially thought to represent a dermatofibroma with monster cells (DFMC), but was subsequently diagnosed as MCAH.
Conclusion: Multinucleate cell angiohistiocytoma, DFMC, and GCF have several overlapping clinical and immunohistochemical characteristics. Therefore, clinical presentation cannot be solely relied upon to differentiate MCAH from DFMC. The diagnosis should be made after considering their histological characteristics supplemented by clinical presentation and immunohistochemical differences.
Keywords: Dermatofibroma, Giant cell fibroblastoma, Multinucleate cell angiohistiocytoma
SUPPORTING INFORMATION
Author Contributions
Ahmed Shah - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Samih Salama - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Gabriella Gohla - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Salem Alowami - Conception of the work, Design of the work, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementThis case does not use any specific patient identifiers, and the pictures are of microscopic histology and immunohistochemistry that cannot be used for patient identification purposes. In the department of pathology, we do not directly interact with patients, but all efforts have been made in great detail to anonymize the case as much as possible.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Ahmed Shah et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
