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Case Report
Candida krusei-induced colitis: A rare opportunistic infection
1 Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA
2 Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, FL, USA
Address correspondence to:
Jesse L Kresak
MD, 1600 SW Archer Rd, PO Box 100275, Gainesville, FL 32610,
USA
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Article ID: 100042Z11AA2020
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Arfa A, Harrell D, Suman A, Kresak JL. Candida krusei-induced colitis: A rare opportunistic infection. J Case Rep Images Pathol 2020;6:100042Z11AA2020.ABSTRACT
Introduction: Candida colitis is a very rare condition that affects mainly immunocompromised patients. Most of the reported cases are Candida albicans infections with only one reported case of Candida glabrata and Candida tropicalis.
Case Report: Our patient, a 68-year-old man with multiple myeloma status post two autologous stem cell transplants and one allogeneic transplant, to the best of our knowledge is the first reported case in the literature of Candida krusei-induced colitis. C. krusei, best known for its role in the production of chocolate, is found as a commensal in the human microbiome and rarely presents as an opportunistic pathogen. It is intrinsically resistant to fluconazole and thus accurate diagnosis is critical for proper treatment. Severe immunodeficiency is a high-risk factor for the development of a C. krusei infection, particularly in patients with hematologic malignancies, stem cell transplants, and interestingly, in patients exposed to azole antifungals and corticosteroid therapy.
Conclusion: This case illustrates the first example of C. krusei colitis. C. krusei is a rare cause of disseminated fungal infection and it is important to recognize due to its resistance to fluconazole and its mortality.
Keywords: Candidemia, Candida colitis, Candida krusei, Fungal colitis
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Author Contributions
Ahmed Arfa - Conception of the work, Design of the work, Acquisition of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Danielle Harrell - Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Amitabh Suman - Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Jesse L Kresak - Acquisition of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Ahmed Arfa et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
