 |
Case Report
Malignant chondroid syringoma: A case report and literature review
1 Assistant Professor, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
2 Associate Professor, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
3 Professor, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Address correspondence to:
Pooja Vasudev
Assistant Professor, Department of Pathology and Molecular Medicine, St. Joseph′s Healthcare, L222-5, St Luke Wing, 50 Charlton Avenue East, Hamilton, ON L8N 4A6,
Canada
Message to Corresponding Author
Article ID: 100046Z11PV2020
Access full text article on other devices
Access PDF of article on other devices
How to cite this article
Vasudev P, Gohla G, Salama S, Alowami S. Malignant chondroid syringoma: A case report and literature review. J Case Rep Images Pathol 2020;6:100046Z11PV2020.ABSTRACT
Introduction: Malignant mixed tumor of the skin/malignant chondroid syringoma (MCS) is a very rare adnexal tumor that is considered as the malignant counterpart of the benign mixed tumor/benign chondroid syringoma (BSC) of the skin. It usually arises de novo in the extremities and takes an unpredictable clinical course with high incidence of local recurrence, distance metastasis, and death. We present a rare case of malignant chondroid syringoma of the forearm which metastasized to the axillary lymph node despite aggressive local treatment.
Case Report: An 83-year-old male with history of numerous prior cutaneous neoplasms, presented with a forearm nodular keratotic lesion, clinically thought to be an invasive squamous cell carcinoma. Accurate histopathological examination revealed a completely excised malignant chondroid syringoma. The patient underwent wide local re-excision of the scar, followed by four weeks of local radiotherapy. Although there was no evidence of any local recurrence, he developed axillary lymph node metastasis four years after the initial diagnosis, for which he underwent axillary lymph node dissection.
Conclusion: Malignant chondroid syringomas are exceedingly rare tumors, but with a high incidence of recurrence, metastasis, and death. These cases need to be diagnosed with strict histopathological criteria. Current treatment of MCS comprises of complete excision with wide margins plus or minus local radiotherapy to prevent local recurrence. Close follow-up and staging are recommended to aid in early detection of recurrence or metastasis.
Keywords: Chondroid syringoma, Malignant mixed tumor, Metastatic, Skin adnexal tumor
SUPPORTING INFORMATION
Author Contributions
Pooja Vasudev - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Gabriela Gohla - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Samih Salama - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Salem Alowami - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementThis case does not use any specific patient identifiers, and the pictures are of microscopic histology and immunohistochemistry that cannot be used for patient identification purposes. In the department of pathology, we do not directly interact with patients, but all efforts have been made in great detail to anonymize the case as much as possible.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Pooja Vasudev et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
