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Case Report
Mixed neuroendocrine and squamous rectal carcinoma: A poor prognosis
1 Surgical Intern, Department of Colorectal Surgery, Galway Clinic, Doughiska, Galway, Ireland
2 Consultant Pathologist, Department of Pathology, Galway Clinic, Doughiska, Galway, Ireland
3 Consultant Colorectal Surgeon, Department of Colorectal Surgery, Galway Clinic, Doughiska, Galway, Ireland
4 Royal College of Surgeons in Ireland, Ireland
Address correspondence to:
Radha Senaratne
Suite 4, Galway Clinic, Doughiska, Galway,
Ireland
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Article ID: 100050Z11RS2021
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How to cite this article
Senaratne R, Curran S, Joyce W. Mixed neuroendocrine and squamous rectal carcinoma: A poor prognosis. J Case Rep Images Pathol 2021;7:100050Z11RS2021.ABSTRACT
Introduction: Colorectal cancer is one of the most common cancers diagnosed globally with the majority being adenocarcinomas. Mixed tumors can occur, however, it is very rare for no adenocarcinoma component to be present.
Case Report: We describe a patient who presented with a recto-sigmoid tumor and subsequently underwent a low anterior resection. She unfortunately developed metastatic disease and died three months after surgery. Histological analysis of the resected specimen showed a mixed neuroendocrine and squamous carcinoma with no features of adenocarcinoma.
Conclusion: Mixed neuroendocrine carcinoma with a squamous component is a very unusual histopathological subtype of colorectal cancer. It can metastasize rapidly and carries a poor prognosis.
Keywords: Carcinoma, Neuroendocrine, Rectal cancer, Squamous
SUPPORTING INFORMATION
Author Contributions
Radha Senaratne - Acquisition of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Stephanie Curran - Conception of the work, Design of the work, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
William Joyce - Conception of the work, Design of the work, Acquisition of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient’s next-of-kin for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Radha Senaratne et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
