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Case Series
Myositis and osteomyelitis due to radiotherapy-related fistulae in locally advanced cervical cancer
1 Resident of Medical Oncology Department, Hospital Virgen de la Salud, Toledo, Spain
2 Resident of Internal Medicine Department, Hospital Virgen de la Salud, Toledo, Spain
3 Nephrologist of Nephrology Department, Hospital Virgen de la Salud, Toledo, Spain
4 Oncologist of Medical Oncology Department, Hospital Virgen de la Salud, Toledo, Spain
5 Oncologist Head of Department of Medical Oncology Department, Hospital Virgen de la Salud, Toledo, Spain
Address correspondence to:
Miguel Borregón Rivilla
Calle Fuenterrabía, nº4, piso 6º centro izquierda, Madrid 28014,
Spain
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Article ID: 100051Z08MR2019
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Borregón Rivilla M, Serrano Romero de Ávila V, Acevedo Ribó M, Cárdenas JD, Chacón López-Muñiz JI, Esteban Esteban C. Myositis and osteomyelitis due to radiotherapy-related fistulae in locally advanced cervical cancer. J Case Rep Images Obstet Gynecol 2019;5:100051Z08MR2019.ABSTRACT
Enteric and urinary fistulae secondary to chemoradiation for carcinoma of the uterine cervix are devastating uncommon conditions with a significant impact in quality of life. They can also originate multiple disturbances and complications, mainly recurrent infections. We present two women with locally advanced cervical cancer treated with radiation who presented myositis and osteomyelitis secondary to pelvic infections due to radiation-induced fistulae. Recognizing and managing these complications need a high level of suspicion. Treatment is based on a multimodal approach which includes antimicrobial therapy, nutritional support, and surgical intervention. Revision of the literature is presented.
Keywords: Cervical cancer survivors, Myositis, Osteomyelitis, Pelvic sepsis, Radiation-induced fistulae, Secondary amyloidosis
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Acknowledgments
The authors of this manuscript thank to both patients whose clinical cases have been exposed their help to the contribution of medical science development. We would like to thank Dr. Carmen Esteban, Medical Oncologist of Medical Oncology Department in Hospital Virgen de la Salud, for her contribution to the education of new oncologist residents. She has always been open to help and guide clinical and researching projects and she is the light that leads this report and many other researching activities. We would like to thank Dr. Chacón, Head of Medical Oncology Department in Hospital Virgen de la Salud, for his contribution to the education of new oncologist residents and his support in every researching project. As head of department, he has always been approachable and has provided us his experience and science.
Author ContributionsMiguel Borregón Rivilla - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Vicente Serrano Romero de Ávila - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mercedes Acevedo Ribó - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Juan David Cárdenas - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
José Ignacio Chacón López-Muñiz - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Carmen Esteban Esteban - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2019 Miguel Borregón Rivilla et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
