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Case Report
An unusual case of metastatic angiosarcoma in bone marrow, presenting with thrombocytopenia
1 MBChB, Department of Pathology, United Christian Hospital, Hong Kong
2 MBBS, FRCPath, FHKCpath, FHKAM, Department of Pathology, United Christian Hospital, Hong Kong
3 MBBS, FRCPC (Haematological Pathology), FHKCPath, FHKAM, United Christian Hospital, Hong Kong
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Chun-hai LO
Department of Pathology, United Christian Hospital,
Hong Kong
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Article ID: 100051Z11CO2021
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LO CH, CHENG SY, CHOW YD. An unusual case of metastatic angiosarcoma in bone marrow, presenting with thrombocytopenia. J Case Rep Images Pathol 2021;7:100051Z11CO2021.ABSTRACT
Introduction: Tumors in bone marrow are usually hematolymphoid or epithelial in origin. Metastatic sarcoma to bone marrow is relatively rare. Angiosarcoma is an uncommon malignant sarcoma of endothelial cells in origin, and principally spread hematogenously. Lung is the most common site for metastases, and other rarer sites for metastases include liver, lymph nodes, and the brain . Metastasis to bone marrow is rarely reported.
Case Report: This is a case of bone marrow involvement by metastatic angiosarcoma in an 80-year-old Chinese man. He presented with persistent thrombocytopenia few years after the diagnosis of angiosarcoma at the scalp and temporal region. The case is described with a review of literature. Clinical information, histological and immunohistochemical features are described. Histological exam of the bone marrow trephine biopsy confirmed the diagnosis of metastatic angiosarcoma.
Conclusion: Angiosarcoma is a highly aggressive vascular neoplasm. In patients with known history of angiosarcoma, clinicians should always bear in mind the possibility of bone marrow metastasis as the cause of persistent thrombocytopenia. Prompt investigations including bone marrow trephine biopsy should be performed.
Keywords: Angiosarcoma, Bone marrow, Metastasis
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Author Contributions
Chun-hai LO - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Shui-ying CHENG - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Eudora Yu-de CHOW - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Chun-hai LO et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
