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Case Report
A discussion of immunohistochemistry in diagnosing a rare case of an adenosquamous carcinoma of the gallbladder
1 Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA
2 New York Institute of Technology College of Osteopathic Medicine, Glen Head, NY, USA
3 Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA
4 Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ, USA
Address correspondence to:
Konstantinos Damiris
Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ,
USA
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Article ID: 100052Z11KD2021
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Damiris K, Seltzer ES, Galan M, Ahlawat SK. A discussion of immunohistochemistry in diagnosing a rare case of an adenosquamous carcinoma of the gallbladder. J Case Rep Images Pathol 2021;7:100052Z11KD2021.ABSTRACT
Introduction: Gallbladder cancer is rare, with adenosquamous carcinoma being an even more uncommon variant, presenting at advanced stages with right upper quadrant and epigastric pain.
Case Report: Here we describe a case of an elderly patient with extensive comorbidities presenting with weakness, pain, and unintentional weight loss who was found to have a large (11.9 × 6.2 × 6.8 cm) heterogeneous right upper quadrant mass. In an effort to provide symptomatic relief, the patient underwent an open cholecystectomy with avoidance of more extensive operations. Pathology reported invasive poorly differentiated adenosquamous carcinoma positive for cytokeratin-19 (CK-19), p63, CK 5/6, CK 8/18, and polyclonal carcinoembryonic antigen (CEA) (focal).
Conclusion: With the aid of immunohistochemistry, the tumor with extensive squamous differentiation was diagnosed as adenosquamous carcinoma of the gallbladder adenosquamous carcinoma of the gallbladder.
Keywords: Adenosquamous carcinoma, Gallbladder, Immunohistochemistry
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Author Contributions
Konstantinos Damiris - Conception of the work, Design of the work, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Emily S Seltzer - Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mark Galan - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Sushil K Ahlawa - Conception of the work, Design of the work, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Konstantinos Damiris et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
