 |
Case Report
An autopsy case report of sudden collapse: Diffuse large B cell lymphoma with predominant intravascular distribution and bone marrow involvement
1 Department of Pathology, United Christian Hospital, Hong Kong
Address correspondence to:
Chun-hai LO
Department of Pathology, United Christian Hospital,
Hong Kong
Message to Corresponding Author
Article ID: 100053Z11CO2021
Access full text article on other devices
Access PDF of article on other devices
How to cite this article
LO C-h, CHENG S-y. An autopsy case report of sudden collapse: Diffuse large B cell lymphoma with predominant intravascular distribution and bone marrow involvement. J Case Rep Images Pathol 2021;7:100053Z11CO2021.ABSTRACT
Introduction: Diffuse large B cell lymphoma is a type of high grade B cell lymphoma. There is one variant named as intravascular large B cell lymphoma (IVLBCL), which is an uncommon entity with high mortality rate. The diagnosis could be difficult as the clinical presentation could be subtle and sometimes a post-mortem diagnosis. The latter variant can show bone marrow involvement, especially in Asian cases.
Case Report: We report a case of diffuse large B cell lymphoma with predominant intravascular distribution presenting as sudden death. The diagnosis was made by histology examination of the tissue at various parts of body. Subsequent immunohistochemical studies confirmed the presence of lymphoma cells inside blood vessels. Bone marrow involvement is noted.
Conclusion: This case should raise the alertness of malignant lymphoma cells inside blood vessels during autopsy. Awareness of such entity during ante-mortem biopsy and autopsy helps to delineate the cause of clinical deterioration.
Keywords: Diffuse large B cell lymphoma, Intravascular large B cell lymphoma, Sudden death
SUPPORTING INFORMATION
Author Contributions
Chun-hai LO - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Shui-ying CHENG - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Chun-hai LO et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
