 |
Case Report
Chronic constipation leading to total colectomy: A rare case to illustrate the controversial entity of intestinal neuronal dysplasia
1 MD, MS, Clinical Fellow, Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
2 MD, PhD, Resident Physician, Department of Pathology, NYU Langone Long Island Hospital, Mineola, NY, USA
3 MD, Clinical Associate Professor, Department of Pathology, NYU Langone Long Island Hospital, Mineola, NY, USA
Address correspondence to:
Mona Deerwester
MD, MS, Surgical Pathology Fellow, Department of Pathology, Vanderbilt University Medical Center, 1211 Medical Center Dr., VUH 3020, Nashville, TN,
USA
Message to Corresponding Author
Article ID: 100055Z11MD2021
Access full text article on other devices
Access PDF of article on other devices
How to cite this article
Deerwester M, Weng K, Drexler S. Chronic constipation leading to total colectomy: A rare case to illustrate the controversial entity of intestinal neuronal dysplasia. J Case Rep Images Pathol 2021;7:100055Z11MD2021.ABSTRACT
Introduction: Intestinal neuronal dysplasia (IND) encompasses a group of histological anomalies of bowel innervation characterized by clinical symptoms of constipation, abdominal pain, and delayed intestinal transit time. William Meier-Ruge first described IND in 1971 as malformation of the enteric plexus. However, despite numerous scientific research conducted with over 250 articles published, IND remains a controversial entity due to lack of consensus on diagnostic criteria.
Case Report: We present a unique case of a patient with chronic constipation and with clinical symptoms consistent with IND but the histopathological findings revealed hypoganglionosis of Meissner’s plexus and hyperganglionosis of Auerbach’s plexus, neither of which met the diagnostic criteria of IND.
Conclusion: This unique case illustrates the controversy of the diagnostic criteria of IND and exemplifies the need for definite treatment regardless of the diagnosis.
Keywords: Chronic constipation, Colectomy, Intestinal neuronal dysplasia
SUPPORTING INFORMATION
Author Contributions
Mona Deerwester - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Katherine Weng - Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Steven Drexle - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Mona Deerwester et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
