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Case Report
Diagnosis and treatment of Waldenstrom’s macroglobulinemia in a twin pregnancy
1 Kansas University School of Medicine, Kansas City, Kansas 66160, USA
2 Department of Obstetrics & Gynecology, Kansas University Medical Center, Kansas City, Kansas 66160, USA
Address correspondence to:
Brian Harrison
Kansas University School of Medicine, Kansas City, Kansas 66160,
USA
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Article ID: 100058Z08BH2020
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Harrison B, Winchester ML. Diagnosis and treatment of Waldenstrom’s macroglobulinemia in a twin pregnancy. J Case Rep Images Obstet Gynecol 2020;6:100058Z08BH2020.ABSTRACT
Introduction: Waldenstrom’s macroglobulinemia (WM) is a rare neoplastic disease with bone marrow involvement and overproduction of immunoglobulin M (IgM). The clinical manifestations range from asymptomatic disease diagnosed incidentally to severe pancytopenia and hyperviscosity syndrome. This disease is incredibly rare in women of reproductive age, let alone pregnancy.
Case Report: The patient presented here was diagnosed with WM during her first trimester. Due to disease severity, she required both plasmapheresis and rituximab. She delivered healthy twin infants vaginally at 34 weeks gestation, after induction of labor for preeclampsia with severe features.
Conclusion: This case highlights the need for a high index of suspicion, and early multidisciplinary involvement to obtain good outcomes for the mother-fetal dyad.
Keywords: Lymphoma, Pregnancy, Waldenstrom’s macroglobulinemia
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Acknowledgments
We thank our anonymous patient and her desire to contribute to this field for the betterment of others.
Author ContributionsBrian Harrison - Acquisition of data, Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mae-Lan Winchester - Conception of the work, Design of the work, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Brian Harrison et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
