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Chronic intestinal pseudo-obstruction due to eosinophilic myenteric ganglionitis: A report of two cases
1 Carle Illinois College of Medicine, 807 S. Wright Street, Champaign, IL 61820, USA
2 Department of Colorectal Surgery, Carle Foundation Hospital, 611 W. Park Street, Urbana, IL 61801, USA
3 Department of Pathology, Carle Foundation Hospital, 611 W. Park Street, Urbana, IL 61820, USA
Address correspondence to:
Ike Uzoaru
MD, Department of Pathology, Carle Foundation Hospital and Carle Illinois College of Medicine, 611 W. Park Street, Urbana, IL 61801,
USA
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Article ID: 100059Z11KC2022
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Cordner K, Tender P, Uzoaru I. Chronic intestinal pseudo-obstruction due to eosinophilic myenteric ganglionitis: A report of two cases. J Case Rep Images Pathol 2022;8:100059Z11KC2022.ABSTRACT
Eosinophilic myenteric ganglionitis (EMG) is a rare cause of chronic intestinal pseudo-obstruction (CIPO). While patients are typically in the first decade of life, and predominantly female, rare cases can be seen in adults. Patients present with constipation, abdominal distention, and tenderness with surgery as the mainstay of treatment. While outcomes are normally favorable after surgery, malnutrition, and surgical errors can lead to postoperative complications. A high index of suspicion for EMG, albeit rare, should be entertained in cases of CIPO since these patients usually have normal colonoscopy and/or biopsies due to the involvement of the myenteric plexus and sparing of the submucosal plexus. We report two cases of patients who underwent colon resection for CIPO complicated by sigmoid volvulus, and histologically characterized by colonic EMG and hypoganglionosis.
Keywords: Chronic intestinal pseudo-obstruction, Eosinophilic myenteric ganglionitis, Hypoganglionosis, Megacolon, Sigmoid volvulus
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The authors acknowledge here individuals who contributed to the work but do not qualify for authorship.
Author ContributionsKeith Cordner - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Paul Tender - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Ike Uzoaru - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2022 Keith Cordner et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
