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Case Report
Primary pulmonary malignant melanoma versus metastatic melanoma with indeterminate primary site
1 Resident, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
2 Associate Professor, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
3 Associate Professor, Department of Surgery, Division of Thoracic Surgery, McMaster University, Hamilton, Ontario, Canada
4 Professor, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Address correspondence to:
Harpreet Rai
Department of Pathology and Molecular Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8,
Canada
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Article ID: 100062Z11HR2022
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Rai H, Naqvi AH, Hanna WC, Alowami SO. Primary pulmonary malignant melanoma versus metastatic melanoma with indeterminate primary site. J Case Rep Images Pathol 2022;8:100062Z11HR2022.ABSTRACT
Introduction: Primary malignant melanoma of the lung is an extremely rare entity with a dismal prognosis.
Case Report: Herein, we present a case of primary malignant melanoma of the lung in a 67-year-old woman with a history of chest infection and a suspicious lesion on a chest X-ray. Computed tomography scan of the chest confirmed a nodule in the left lower lobe. Positron emission tomography showed a hypermetabolic tumor with no evidence of metastatic disease or mediastinal lymphadenopathy. The patient subsequently underwent surgery. Histopathological examination, supported by immunohistochemical analysis, was in accordance with malignant melanoma.
Conclusion: Since the published data focusing on cases of primary malignant melanoma of the lung are limited, the pathological features of these melanomas, their histogenesis, clinical behavior, and the possible therapeutic options are not well established.
Keywords: BRAF, Lung, Malignant melanoma
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Author Contributions
Harpreet Rai - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Asghar H Naqvi - Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Waël C Hanna - Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Salem O Alowami - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2022 Harpreet Rai et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
