 |
Case Report
Microcystic/reticular schwannoma of the lower leg: Case report with review of literature
1 Department of Human Pathology, Juntendo University School of Medicine, Tokyo 113-8421, Japan
2 Intractable Disease Research Center, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, Japan
3 Department of Medicine for Orthopaedics and Motor Organs, Juntendo University School of Medicine, Tokyo 113-8421, Japan
Address correspondence to:
Tsuyoshi Saito
MD, PhD, Department of Human Pathology, Juntendo University School of Medicine, Tokyo 113-8421,
Japan
Message to Corresponding Author
Article ID: 100063Z11TS2022
Access full text article on other devices
Access PDF of article on other devices
How to cite this article
Saito T, Kubota D, Sasa K, Hasegawa N, Hayashi T, Takagi T, Ishijima M. Microcystic/reticular schwannoma of the lower leg: Case report with review of literature. J Case Rep Images Pathol 2022;8(2):1–5.ABSTRACT
Introduction: Microcystic/reticular schwannoma is a distinctive histopathological variant of schwannoma, which is rare. Its occurrence in the subcutaneous soft tissue of the lower extremity has rarely been reported.
Case Report: We report a microcystic/reticular schwannoma arising from a subcutaneous lesion on the lower leg of a 33-year-old man. The patient noticed a subcutaneous mass on the right lower leg six months before admission and experienced radiation pain in the left lower leg. Magnetic resonance imaging revealed a well-demarcated mass with 11-mm maximum diameter with low signal intensity on T1-weighted imaging and high signal intensity on T2-weighted imaging in the subcutaneous region of the right lower leg. Histological examination revealed a cellular area at the periphery of the tumor, although the majority of the tumor showed a microcystic/reticular structure within the myxo-collagenous stroma. The current case was well capsulated and did not show an infiltrative growth pattern. In addition, aggregation of foamy macrophages was frequently seen, although it was reported as a rare feature. After complete surgical excision with clean resection margins, the patient is well, with no evidence of tumor recurrence on follow-up after postoperative 14 months.
Conclusion: In this case, infrequent findings for microcystic/reticular schwannoma were observed, although the presence of the classical Antoni A area was helpful for the diagnosis of microcystic/reticular schwannoma.
Keywords: Foamy cells, Lower extremity, Microcystic/reticular schwannoma, S-100
SUPPORTING INFORMATION
Author Contributions
Tsuyoshi Saito - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Daisuke Kubota - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Keita Sasa - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Nobuhiko Hasegawa - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Takuo Hayashi - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Tatsuya Takagi - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Muneaki Ishijima - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2022 Tsuyoshi Saito et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
