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Case Report
Primary liver yolk sac tumor with lung metastasis in adolescence: Rare case report
1 Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
2 Department of Health Sciences, Carleton University, Ottawa, Ontario, Canada
3 Department of Laboratory Medicine, Children’s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
4 Faculty of Medicine, Libyan International Medical University, Benghazi, Libya
5 Department of Pathology, The Ottawa Hospital, Ottawa, Ontario, Canada
Address correspondence to:
Joseph de Nanassy
Pediatric Pathologist, Children’s Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, ON K1H 8L1,
Canada
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Article ID: 100081Z11YN2024
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How to cite this article
Nasr Y, Mehdi S, Tristani L, Alowami M, Chernetsova E, de Nanassy J. Primary liver yolk sac tumor with lung metastasis in adolescence: Rare case report. J Case Rep Images Pathol 2024;10(2):22–26.ABSTRACT
Introduction: Germ cell tumors (GCTs) often arise within the gonads but occasionally appear within the extragonadal areas. Yolk sac tumors (YSTs), a type of GCT, are most often found in infants and adolescents due to puberty. However, primary liver YST cases are rare, with only one other reported case in the adolescent population.
Case Report: The current case examines a 15-year-old female patient experiencing significant weight loss, respiratory issues, and fevers. After her blood work displayed high alpha-fetoprotein (AFP) levels, a biopsy revealed a stage four primary liver YST with lung metastasis. The infrequency and primary location of the tumor, combined with her age, create challenges in diagnosis and treatment. Due to its rarity, the reporting of this case may aid in diagnosis when encountered. We highlight and present our experience of management and prognosis of primary-hepatic YST when encountered in adolescents.
Conclusion: At two years follow-up, the patient showed no evidence of recurrence or metastasis.
Keywords: Germ cell tumor, Hepatic metastasis, Immunohistochemistry, Pediatric, Yolk sac tumor
SUPPORTING INFORMATION
Author Contributions
Youssef Nasr - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Samira Mehdi - Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Lauren Tristani - Acquisition of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Moaz Alowami - Analysis of data, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Elizaveta Chernetsova - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Joseph de Nanassy - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Youssef Nasr et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
