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Case Report
A cellular fibroepithelial tumor of the breast: A case report
1 MD, Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
2 MD, Department of Pathology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
3 MD, PhD, Department of Pathology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
4 MD, PhD, Department of Surgical Oncology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
5 MD, PhD, Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
Address correspondence to:
Vanhoenacker Anne-Sophie
MD, Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven,
Belgium.
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Article ID: 100082Z10VA2021
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Vanhoenacker AS, Waumans L, Floris G, Nevelsteen I, Van Ongeval C. A cellular fibroepithelial tumor of the breast: A case report. J Case Rep Images Oncology 2021;7:100082Z10VA2021.ABSTRACT
Introduction: Fibroepithelial breast lesions are biphasic neoplasms characterized by proliferation of both stromal and epithelial cells. They encompass a spectrum of tumors ranging from benign fibroadenoma to potentially fatal malignant phyllodes tumor, with tumors of borderline clinical significance in-between. It is important to correctly characterize each lesion, as this defines management and thus risk of local recurrence and potential distant metastasis in case of malignancy.
Case Report: A 48-year-old woman presented with a palpable retro-areolar lump in the left breast. After core biopsy, the initial pathology report initiated tumorectomy. When the final report stated a borderline phyllodes tumor with incomplete resection, reintervention was needed with wide surgical margins to avoid local recurrence. The local re-excision showed scarring and steatonecrosis as a result of the previous procedure, but no residual lesion. Consequently, there was no need for further surgical intervention.
Conclusion: Fibroepithelial lesions (FEL) of the breast are a wide variety of lesions with distinct management based on the exact pathologic character. Core needle biopsy poses a risk of sampling error due to intratumoral heterogeneity that sometimes may be found in cellular FEL. As a consequence, upgrading at the time of the excision specimen can frequently occur with need of reintervention.
Keywords: Cellular fibroadenoma, Fibroepithelial breast lesions, Periductal stromal tumor, Phyllodes tumor
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Author Contributions
Vanhoenacker Anne-Sophie - Conception of the work, Design of the work, Acquisition of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Waumans Lise - Acquisition of data, Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Floris Giuseppe - Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Nevelsteen Ines - Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Van Ongeval Chantal - Analysis of data, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Vanhoenacker Anne-Sophie et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
