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Case Report
Epithelioid hemangioma of the skull: Rare case report
1 Student, Interdisciplinary Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
2 Student, Medical Science, Western University, London, Ontario, Canada
3 Clinical Researcher, Department of Pathology, Children’s Hospital of Eastern Ontario, Canada
4 Pathologist, Department of Pathology, Children’s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
5 Oncologist, Division of Hematology/Oncology, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
6 Radiologist, Department of Diagnostic Imaging, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
Address correspondence to:
Nagwa Wilson
401 Smyth Rd, Ottawa, Ontario K1H 8L1,
Canada
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Article ID: 100084Z11AR2025
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Rashwan A, Riarh C, Tristani L, de Nanassy J, Ramphal R, Wilson N. Epithelioid hemangioma of the skull: Rare case report. J Case Rep Images Pathol 2025;11(1):1–7.ABSTRACT
Introduction: Epithelioid hemangiomas (EH) are benign vascular tumors that commonly occur in the skin, subcutis, and bone—most typically arising as nodules in the neck and head region. Pediatric cases with atypical presentations remain rare and challenging.
Case Report: The following outlines the case of a 2-year-old male who presented with a bump and swelling on the left side of his head. Imaging tests identified multiple, hyperdense, and focally ring-enhancing intra-axial lesions located mainly at the gray-white matter junction of bilateral frontal left-sided parietal, left-sided occipital, and left-sided temporal lobes. In addition, multiple lytic lesions were seen in the calvarium. Pathology confirmed EH. While one lesion required surgical resection, the remaining lesions showed spontaneous regression during follow-up.
Conclusion: This case highlights the diagnostic and management challenges associated with pediatric EH involving the head, including intracranial involvement. The patient’s unique presentation, age, and lesion involution expand the understanding of EH beyond its typical manifestation.
Keywords: Epithelioid hemangioma, Pediatric, Skull
SUPPORTING INFORMATION
Author Contributions
Ayah Rashwan - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Chanpreet Riarh - Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Lauren Tristani - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Joseph de Nanassy - Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Raveena Ramphal - Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Nagwa Wilson - Acquisition of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Ayah Rashwan et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
