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Case Report
Kasabach–Merritt syndrome, not only a pediatric condition: An autopsy case report and review of literature
1 Department of Pathology, Northwell Health, Greenvale, NY 11552, USA
2 Department of Surgery, Lincoln Medical Center, Bronx, NY 10451, USA
3 Department of Pathology, New York University, Langone-Long Island, Mineola, NY 11501, USA
Address correspondence to:
Zarrin Hossein-Zadeh
MD, Department of Pathology at Northwell Health/Donald and Barbara Zucker School of Medicine at Hofstra, Greenvale, NY,
USA
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Article ID: 100085Z11ZZ2025
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Hossein-Zadeh Z, Rivero-Soto R, Hon JDC. Kasabach–Merritt syndrome, not only a pediatric condition: An autopsy case report and review of literature. J Case Rep Images Pathol 2025;11(1):8–12.ABSTRACT
Kasabach–Merritt syndrome (KMS), also known as hemangioma with thrombocytopenia, is a rare vascular disease characterized by thrombocytopenia, anemia, disseminated intravascular coagulation (DIC), and vascular lesions. It often occurs during infancy and the neonatal period and rarely in adults. The syndrome presents with consumptive coagulopathy initiated within a vascular tumor, mainly tufted angiomas or Kaposiform hemangioendotheliomas, and less commonly, hepatic and/or biliary hemangiomas. We report a case of a 41-year-old female with a recent diagnosis of biopsy proven biliary-type hemangioma of the liver, undergoing fertility treatment, who developed consumptive coagulopathy and disseminated intravascular coagulation shortly following a liver biopsy procedure, and ultimately demised. Based on the review of the literature, we present the first adult case of KMS where the diagnosis was made post-mortem. Given the rarity of this condition, particularly in the adult population, we believe our case adds value to the field of critical care medicine, coagulopathies, and forensic medicine.
Keywords: Consumptive coagulopathy, Hepatic hemangioma, Kasabach–Merritt syndrome (KMS)
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Author Contributions
Zarrin Hossein-Zadeh - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Roberto J Rivero-Soto - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Jane Date C Hon - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Zarrin Hossein-Zadeh et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
