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Case Report
Primary splenic non-germinal center B-cell large lymphoma with associated granulomatous inflammation: A rare presentation
1 Department of Pathology, Mohammed V Military Training Hospital, Rabat, Morocco
2 Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, 10100 Rabat, Morocco
3 Department of Radiology, Mohammed V Military Training Hospital, Rabat, Morocco
4 Department of Internal Medicine, Mohammed V Military Training Hospital, Rabat, Morocco
Address correspondence to:
Sara El Ghaffouli
Department of Pathology, Mohammed V Military Training Hospital, Rabat,
Morocco
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Article ID: 100089Z11SG2025
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How to cite this article
El Ghaffouli S, El Graini S, El Bougrini Z, Chahdi H, Essaoudi MA, Oukabli M. Primary splenic nongerminal center B-cell large lymphoma with associated granulomatous inflammation: A rare presentation. J Case Rep Images Pathol 2025;11(1):26–29.ABSTRACT
Introduction: Granulomatous inflammation has been reported in association with both Hodgkin and non- Hodgkin lymphomas. Its presence alongside lymphoma is uncommon and may complicate the diagnostic process.
Case Report: We report the case of a 72-year-old male who presented to our hospital with weight loss, night sweats, and general deterioration. His medical history included urothelial carcinoma treated with Bacillus Calmette–Guérin (BCG) therapy in 2020. Clinical examination revealed splenomegaly extending to the flank. An excisional splenic biopsy confirmed the diagnosis of diffuse large B-cell lymphoma (DLBCL) with associated granulomatous inflammation.
Conclusion: This case illustrates an atypical presentation of DLBCL with granulomatous inflammation, emphasizing the need for careful histopathological assessment in such scenarios.
Keywords: Association, Granulomatous inflammation, Primary splenic DLBCL
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Author Contributions
Sara El Ghaffouli - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Soumya El Graini - Conception of the work, Design of the work, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Zineb El Bougrini - Conception of the work, Design of the work, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Hafsa Chahdi - Conception of the work, Design of the work, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mohamed Amine Essaoudi - Conception of the work, Design of the work, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mohamed Oukabli - Conception of the work, Design of the work, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Sara El Ghaffouli et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
