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Case Report
Bladder extra-gastrointestinal stromal tumor in an elderly patient in Uganda: A case report
1 Department of Pathology, Uganda Cancer Institute, Kampala, Uganda
2 Department of Pathology, Uganda Christian University, Mukono, Uganda
3 Department of Medical Oncology, Uganda Cancer Institute, Kampala, Uganda
Address correspondence to:
Tonny Okecha
Department of Pathology, Uganda Cancer Institute,
Uganda
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Article ID: 100090Z11TO2025
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Okecha T, Bakenga A, Waiswa A, Mawanda A, Nyakato V, Niyonzima N. Bladder extra-gastrointestinal stromal tumor in an elderly patient in Uganda: A case report. J Case Rep Images Pathol 2025;11(1):30–34.ABSTRACT
Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract (GI). They arise from the interstitial cells of Cajal or similar cells. Gastrointestinal stromal tumors that occur primarily outside the GI tract are termed extra-gastrointestinal stromal tumor (EGIST). These tumors are extremely rare and very few cases have been reported to date.
Case Report: We report a case of a 75-year-old male who presented with a bladder mass. The patient presented with hematuria and lower urinary tract symptoms of dribbling, straining and incomplete voiding of urine. Pelvic computed tomography scan showed a well-defined homogenous mass in the urinary bladder. The tumor was partially surgically resected and histology revealed a spindle-shaped tumor that was initially reported as fibrosarcoma. However, a histology review was done and immunohistochemistry staining was positive for CKIT, CD34, and DOG-1. A diagnosis of EGIST was made. There has not been any case of EGIST reported in Uganda to the best of our knowledge.
Conclusion: This case highlights the rarity of EGISTs, emphasizing the need for accurate diagnosis through immunohistochemistry and increased awareness for clinical management.
Keywords: Bladder, Extra-gastrointestinal, Stromal tumor, Uganda
SUPPORTING INFORMATION
Author Contributions
Tonny Okecha - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Alex Bakenga - Acquisition of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Ali Waiswa - Conception of the work, Design of the work, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Anatoli Mawanda - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Veronica Nyakato - Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Nixon Niyonzima - Acquisition of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
