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Case Report
Globe-salvaging treatment of amelanotic uveal melanoma with posterior extraocular extension
1 Division of Ocular Oncology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA
2 Department of Pathology, Columbia University Irving Medical Center, New York, NY, USA
3 Department of Ophthalmology, Albany Medical Center, Albany, NY, USA
Address correspondence to:
Arpita S Maniar
MD, Department of Ophthalmology, Edward S. Harkness Eye Institute, 635 West 165th Street, New York, NY 10032,
USA
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Article ID: 100091Z10AM2021
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Maniar AS, Niedt G, Langevin ST, Marr BP. Globe-salvaging treatment of amelanotic uveal melanoma with posterior extraocular extension. J Case Rep Images Oncology 2021;7:100091Z10AM2021.ABSTRACT
Introduction: Extraocular extension (EOE) of uveal melanoma is rare and generally associated with poor systemic prognosis.
Case Report: We report a patient with amelanotic uveal melanoma with an extraocular extension managed with combination of surgical resection of the posterior extraocular extension along with transpupillary thermotherapy (TTT) to the choroidal lesion, thereby salvaging the globe. To the best of our knowledge, we are the first case to report such combination treatment for amelanotic uveal melanoma with posterior extension without evidence of orbital recurrence or systemic metastasis over a follow-up period of thirteen years.
Conclusion: Careful resection of the extraocular tumor component along with aggressive treatment of the primary intraocular tumor may achieve globe salvage in carefully selected cases.
Keywords: Extra ocular extension, Transpupillary thermotherapy, Uveal melanoma
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Author Contributions
Arpita S Maniar - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
George Niedt - Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Spencer T Langevin - Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Brian P Marr - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Arpita S Maniar et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
