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Case Report
Primary melanoma with oral and sinonasal involvement: A rare case report
1 Post Graduation Student, Oral Medicine, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
2 Professor, Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
3 Professor, Oral Radiology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
4 Oral Medicine Service, Oral Medicine, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
5 Professor, Oral Medicine, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
Address correspondence to:
Thamyres Campos Fonsêca
DDS, MSc, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Av. Professor Rodolpho Paulo Rocco, 325, 1º floor, Rio de Janeiro 21941-913,
Brazil
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Article ID: 101108Z01TF2020
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How to cite this article
Fonsêca TC, Abrahão AC, Guedes FR, Junior VM, Janini MER. Primary melanoma with oral and sinonasal involvement: A rare case report. Int J Case Rep Images 2020;11:101108Z01TF2020.ABSTRACT
Introduction: Melanoma is a rare and highly aggressive malignant neoplasm of melanocytic origin, which represents less than 2% of all head and neck malignances, being locally aggressive with poor prognosis.
Case Report: A 57-year-old black man was referred for evaluation of a fast growing palatal swelling lasting five months. Medical history did not include pain or other symptoms and the patient confirmed to be an active smoker for many years. Intraoral examination revealed a large asymmetrical swelling of the right and left palate with a soft consistency and dark pigmentation. A cone beam computed tomography revealed a hypodense image located in the anterior and right side of the maxilla causing great destruction of the alveolar ridge and affecting all right maxillary sinus, the anterior portion of the left sinus and the nasal cavity. It has poor-defined aspect and irregular limits. Microscopically, sheets of atypical melanocytes invading the connective tissue were observed, with perivascular and perineural invasion.
Conclusion: The final diagnosis was melanoma with oral and sinonasal involvement. The patient was submitted to surgical treatment and died few months later.
Keywords: Head and neck cancer, Melanoma, Oral cancer, Oral pathology
SUPPORTING INFORMATION
Author Contributions
Thamyres Campos Fonsêca - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Aline Correa Abrahão - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Fábio Ribeiro Guedes - Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Valdir Meirelles Junior - Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Maria Elisa Rangel Janini - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Thamyres Campos Fonsêca et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
