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Case Report
A rare occurrence of anti-glomerular basement membrane glomerulonephritis complicated by heparin-induced thrombocytopenia
1 Department of Nephrology, Peninsula Health, Frankston, Victoria, Australia
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Rebecca Xu
Department of Nephrology, Peninsula Health, 2 Hastings Road, Frankston, Victoria 3199,
Australia
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Article ID: 101112Z01RX2020
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Xu R, Dang MH. A rare occurrence of anti-glomerular basement membrane glomerulonephritis complicated by heparin-induced thrombocytopenia. Int J Case Rep Images 2020;11:101112Z01RX2020.ABSTRACT
Introduction: Anti-glomerular basement membrane (GBM) disease is a rare condition that often presents as severe glomerulonephritis and pulmonary hemorrhage. Heparin-induced thrombocytopenia (HIT) is a well-known but uncommon complication of heparin exposure that is characterized by autoantibodies against platelet factor 4 (PF4)/heparin complexes. Although these conditions are well described in the literature, the coexistence of HIT and anti-GBM glomerulonephritis is extremely rare.
Case Report: We present a case of a 59-year-old gentleman with newly diagnosed anti-GBM glomerulonephritis who was treated with plasmapheresis and subsequently developed HIT with a delayed manifestation.
Conclusion: This case demonstrates an interesting example of poly-autoimmunity and highlights the importance of platelet monitoring in patients with heparin exposure undergoing plasmapheresis.
Keywords: Glomerulonephritis, Heparin-induced thrombocytopenia
SUPPORTING INFORMATION
Author Contributions
Rebecca Xu - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Minh Huan Dang - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Rebecca Xu et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
