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Case Report
Unusual invasive candidiasis by Candida glabrata in a patient with systemic lupus erythematosus: Case report
1 Graduate Program in Health Sciences, Universidade Estadual de Maringá (UEM), Maringá, PR, Brazil; Department of Physiotherapy Uni Cesumar, Maringá, PR, Brazil
2 Graduate Programa in Health Sciences, Universidade Estadual de Maringá (UEM), Maringá, PR, Brazil
3 Division of Medical Mycology, Teaching and Research Laboratory in Clinical Analyses, Department of Clinical Analysis of State University of Maringa, Avenida Colombo 5790, 87020-900 Maringa, PR, Brazil
Address correspondence to:
Terezinha Inez Estivalet Svidzinski
Universidade Estadual de Maringá, Av. Colombo 5790, Bloco T20, Sala 203, CEP 87020-900, Maringá, Paraná,
Brazil
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Article ID: 101233Z01EF2021
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Ferreira EG, Jarros IC, Veiga FF, Corrêa JL, Pedroso RB, Negri M, Svidzinski TIE. Unusual invasive candidiasis by Candida glabrata in a patient with systemic lupus erythematosus: Case report. Int J Case Rep Images 2021;12:101233Z01EF2021.ABSTRACT
Introduction: Systemic Candida glabrata infections have increased dramatically over the years. However, few studies have associated them with autoimmune diseases, such as systemic lupus erythematosus.
Case Report: We report the case of a patient with systemic lupus erythematosus, admitted with gastrointestinal complaints and oral bleeding. She had an unfavorable clinical evolution with renal failure, requiring hemodialysis and invasive ventilatory support, and fungal septic shock followed by death. The culture grown on the central venous catheter was negative for fungi, but the yeast C. glabrata was observed in all other cultures, as regarding a fungal infection (urine and blood) as for monitoring colonization (tongue and tracheal secretion). The high similarity between the isolated yeasts strongly suggested a common origin of the colonizing yeasts of the oral cavity and respiratory tract, as well as those involved in the infection.
Conclusion: This finding confirms that nosocomial infection by C. glabrata is a reality today and it should not be neglected; furthermore, the management of patients with systemic lupus erythematosus should be rethought because the imbalance of the organic response makes patients susceptible to infections, such as invasive candidiasis.
Keywords: Candidemia, Candida glabrata, Sepse, Systemic lupus erythematosus, Tongue coating
SUPPORTING INFORMATION
Acknowledgments
This study was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimen to Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Paraná (Fundação Araucária).
Author ContributionsElenice Gomes Ferreira - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Isabele Carrilho Jarros - Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Flávia Franco Veiga - Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Jakeline Luiz Corrêa - Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Raíssa Bocchi Pedroso - Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Melyssa Negri - Conception of the work, Design of the work, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Terezinha Inez Estivalet Svidzinski - Conception of the work, Design of the work, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Elenice Gomes Ferreira et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
