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Case Report
A rare case of lung adenocarcinoma with metastases to the breasts bilaterally
1 Resident, Internal Medicine, Flushing Hospital Medical Center, Flushing Hospital, Flushing, NY, USA
2 Medical Student, Internal Medicine, Flushing Hospital Medical Center, Flushing Hospital, Flushing, NY, USA
3 Attending Physician, Hematology-Oncology, Flushing Hospital Medical Center, Flushing Hospital, Flushing, NY, USA
Address correspondence to:
Maysoon T Hussain
Medical Student, Internal Medicine, Flushing Hospital Medical Center, Flushing Hospital, Flushing, NY,
USA
Message to Corresponding Author
Article ID: 101459Z01SD2024
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Dubey S, Hussain MT, Akil M, Gondal N. A rare case of lung adenocarcinoma with metastases to the breasts bilaterally. Int J Case Rep Images 2024;15(2):1–4.ABSTRACT
We present a case of a 65-year-old female with a history of stage IV adenocarcinoma of the lung that metastasized to the bilateral breasts. The breasts are a rare metastatic site for lung adenocarcinoma, with metastases to the breasts bilaterally being further unique. Our patient was diagnosed with stage IV adenocarcinoma of the lung with EGFR exon 20 insertion with metastases to the bone and skin four years prior to presentation, and she underwent a left lower lobotomy and multiple failed therapies. Biopsy of her breast masses revealed TTF (lung marker) positive GATA binding protein 3, GCDFP15, and mammaglobin (breast markers) negative metastatic moderately differentiated adenocarcinoma. Next-generation sequencing studies revealed exon 20 mutation, for which there are few effective targeted therapies. She was considered for therapy with amivantamab but ultimately never received therapy due to multiple hospitalizations, and passed away due to septic shock, likely from empyema versus ESBL E. coli urinary tract infection.
Keywords: Breast metastases, EGFR exon 20 insertion, Lung adenocarcinoma, Non-small cell lung cancer
SUPPORTING INFORMATION
Author Contributions
Saurabh Dubey - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Maysoon T Hussain - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Mohamad Akil - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Nasir Gondal - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Saurabh Dubey et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
