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Case Report
The challenge of clinical diagnosis of cardiac amyloidosis: Case report and literature review
1 Professor of Faculty of Medicine, Department of Internal Medicine, University of Brasília, Brasília-DF, Brazil
2 Medical Academic, Department of Internal Medicine, University of Brasília, Brasília-DF, Brazil
Address correspondence to:
Flávia Zattar Piazera
SQS 109, Block E, Apartment 616, Brasilia, DF 70.372-050,
Brazil
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Article ID: 101461Z01FP2024
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How to cite this article
Piazera FZ, Xavier LD, Cunha NWR, dos Santos TN, de Souza Damaceno AFA. The challenge of clinical diagnosis of cardiac amyloidosis: Case report and literature review. Int J Case Rep Images 2024;15(2):10–14.ABSTRACT
Introduction: Cardiac amyloidosis is a disease caused by the deposition and extracellular accumulation of defective proteins (amyloids) in the myocardium, which can lead to conduction disorders, diastolic dysfunction, and restriction to ventricular filling resulting in reduction of systolic volume and of cardiac output.
Case Report: The patient, a 62-year-old male with a history of ischemic stroke for two months, was referred to the outpatient clinic for investigation of thrombophilia due to echocardiographic changes suggestive of cardiac amyloidosis.
Conclusion: Cardiac amyloidosis is an underdiagnosed disease, and its early diagnosis is crucial for a better prognosis.
Keywords: AL amyloidosis, Cardiac amyloidosis, Diagnostic challenges, Monoclonal gammopathy
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Author Contributions
Flávia Zattar Piazera - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Lucas Dornas Xavier - Conception of the work, Design of the work, Acquisition of data, Drafting the work, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Natalye Wynona Rosário Cunha - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Taís Nunes dos Santos - Conception of the work, Design of the work, Acquisition of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Alex Francisco Antônio de Souza Damaceno - Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Flávia Zattar Piazera et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
