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Case Report
Recurrent sialoblastoma of the parotid and submandibular glands: A case report and review
1 MD, PhD, Associate Professor of Pediatric Surgery, Surgery Department, Medicine School, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
2 Pediatric Surgery Division, Instituto de Puericultura e Pediatria Martagão Gesteira (IPPMG), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
3 MD, PhD, Pediatric Surgery Division, Instituto de Puericultura e Pediatria Martagão Gesteira (IPPMG), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
4 MD, Pediatric Surgery Division, Instituto de Puericultura e Pediatria Martagão Gesteira (IPPMG), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
5 MD, PhD, Full Professor of Pathology, Department of Pathology, Medicine School, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
6 MD, PhD, Adjunct Professor of Pathology, Department of Pathology, Medicine School, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
Address correspondence to:
Ivonete Siviero
MD, PhD, Associate Professor of Pediatric Surgery, Surgery Department, Medicine School, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro,
Brazil
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Article ID: 101498Z01IS2025
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Siviero I, Simões BCB, Méio IB, Sciani DC, Madi K, Chagas VLA. Recurrent sialoblastoma of the parotid and submandibular glands: A case report and review. Int J Case Rep Images 2025;16(1):48–53.ABSTRACT
Introduction: Sialoblastoma is a rare malignant embryonal tumor derived from primitive cells of the salivary glands. It occurs predominantly in the parotid gland and in the neonatal period. In this study, we present a case of sialoblastoma affecting the submandibular and parotid glands and review the literature on the subject.
Case Report: A 19-day-old newborn was presented with a history of a rapidly growing cervical mass since birth. A computed tomography (CT) scan showed a tumor in the left parotid and submandibular glands. He underwent tumor excision at 29 days of age. He had two post-operative recurrences, at 12 and 16 weeks of age. The diagnosis was made by histopathological examination. The tumor involved the facial nerve, and complete resection of the nerve only stopped recurrences after neural excision. The patient has remained relapse free for 18 years but has facial paralysis.
Conclusion: Sialoblastoma should be considered in the differential diagnosis of childhood facial tumors. Despite early diagnosis and extensive resection, there is a propensity for aggressive local recurrences. Neural invasion, capsular rupture, and Ki-67 positivity in immunohistochemical tests are factors that may be decisive in tumor recurrence.
Keywords: Parotid tumor, Salivary malignancy, Sialoblastoma, Submandibular gland
SUPPORTING INFORMATION
Author Contributions
Ivonete Siviero - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Betina Carla Bertrand Simões - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Ivens Baker Méio - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Deborah Câmara Sciani - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Kalil Madi - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Vera Lucia Antunes Chagas - Conception of the work, Design of the work, Acquisition of data, Analysis of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Ivonete Siviero et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
