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Case Report
Mixed diffuse angiomatosis/lymphangiomatosis of the breast in SLE patient: An unusual case report and literature review
1 Resident, Department of Pathology, Imam Abdulrahman Bin Faisal University, King Fahad University Hospital, Al Khobar, Eastern Province, Saudi Arabia
2 Associate Professor, Department of Pathology, Imam Abdulrahman Bin Faisal University, King Fahad University Hospital, Al Khobar, Eastern Province, Saudi Arabia
3 Professor, Department of Surgery, Imam Abdulrahman Bin Faisal University, King Fahad University Hospital, Al Khobar, Eastern Province, Saudi Arabia
4 Assistant Professor, Department of Radiology, Imam Abdulrahman Bin Faisal University, King Fahad University Hospital, Al Khobar, Eastern Province, Saudi Arabia
5 Assistant Professor, Department of Dermatology, Imam Abdulrahman Bin Faisal University, King Fahad University Hospital, Al Khobar, Eastern Province, Saudi Arabia
Address correspondence to:
Tarek El Sharkawy
King Fahd Hospital, Accommodation (Site1), Alaqrabiyah 2916, Unit 134, Khobar 34446, Eastern Province,
Saudi Arabia
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Article ID: 100035Z11ZA2020
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How to cite this article
Al-Turaifi Z, El Sharkawy T, Abdel-Hadi M, Al-Muhana A, Al Brieki S. Mixed diffuse angiomatosis/lymphangiomatosis of the breast in SLE patient: An unusual case report and literature review. J Case Rep Images Pathol 2020;6:100035Z11ZA2020.ABSTRACT
Introduction: Angiomatosis/lymphangiomatosis is a rare, reactive angioproliferative lesion in the skin and is considered to be a subtype in the group of cutaneous reactive angiomatoses. However, few cases of diffuse dermal angiomatosis of the breast (DDAB) have been reported in the literature.
Case Report: In this case report, we present a patient known to have systemic lupus erythematosus (SLE) with mixed diffuse angiomatosis/lymphangiomatosis of both breasts mimicking inflammatory carcinoma. We describe the clinical and histopathologic characteristics, pathogenetic mechanisms, and predisposing risk factors of this rare skin disorder and discuss treatment options.
Conclusion: Currently, there is no agreement on the best therapeutic approach. Isotretinoin and other medical therapies have been used with limited success. Laser therapy and breast reduction appears to be a reliable treatment option for DDAB and might provide definitive treatment.
Keywords: Angiomatosis, Breast, Lymphangiomatosis, SLE
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Author Contributions
Zahra Al-Turaifi - Conception of the work, Design of the work, Acquisition of data, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Tarek El Sharkawy - Conception of the work, Design of the work, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Maha Abdel-Hadi - Conception of the work, Design of the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Afnan Al-Muhana - Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Sara Al Brieki - Acquisition of data, Analysis of data, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Guarantor of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Zahra Al-Turaifi et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
